SkinMedica Age Defence Retinol Complex 1.0 enhances the skin's texture to promote a brighter, more youthful complexion. Formulated for skin tolerant to retinol treatments, it stimulates collagen production and enhances faster cell renewal to minimise the appearance of fine lines and wrinkles. If you have never used a retinol product before, begin by limiting use to twice a week, gradually increasing frequency to every other night, and then advancing to each evening or as tolerated. Mild redness, peeling and irritation is expected when using this product. Use daily sun protection with SPF 20 or higher during use of this product